Publikationen

Englischsprachige Publikationen

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2011

  • B. van den Borst, N. Souren, R. Loos, A. Paulussen, C. Derom, A. Schols and M. Zeegers
    Genetics of maximally attained lung function: A role for leptin?
    Respir Med. 2011, Epub Nov 2
  • L. de Boni, S. Tierling, S. Roeber, J. Walter, A. Giese and H.A. Kretschmar.
    Next-Generation Sequencing Reveals Regional Differences of the a-Synuclein Methylation State Independent of Lewy Body Disease.
    Neuromolecular Med. 2011, Epub Nov 1.
  • B. Diesel, N. Ripoche, R.T. Risch, S. Tierling, J. Walter and A.K. Kiemer.
    Inflammation-induced up-regulation of TLR2 expression in human endothelial cells is independent of differential methylation in the TLR2 promoter CpG island.
    Innate Immunity. 2011, Epub Jul 18.
  • P. Lutsik, L. Feuerbach, J. Arand, T. Lengauer, J. Walter and C. Bock.
    BiQ Analyzer HT: locus-specific analysis of DNA methylation by high-throughput bisulfite sequencing.
    Nucleic Acids Res. 2011, Epub May 11.
  • N. Souren, M. Zeegers.
    Is Hardy-Weinberg on its retreat?
    J Clin Epidemiol. 2011, Epub Apr 2.
  • T. Karius, M. Schnekenburger, J. Gelfi, J. Walter, M. Dicato and M. Diederich.
    Reversible epigenetic fingerprint-mediated glutathione-S-transferase P1 gene silencing in human leukemia cell lines.
    Biochem Pharmacol. 2011, Epub Mar 29.
  • M. Wossidlo, T. Nakamura, K. Lepikhov, C.J. Marques, V. Zakhartchenko, M. Boiani, J. Arand, T. Nakano, W. Reik and J. Walter.
    5-hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming.
    Nat Commun 2011, 2: 241.
  • S. Tierling, C. Sers, A. Lehmann and J. Walter.
    A fast, cost-efficient and sensitive approach for KRAS mutation detection using multiplexed primer extension with IP/RP-HPLC separation.
    Int J Cancer 2011, Epub Mar 8.
  • N.Y. Souren, S. Tierling, J.P. Fryns, C. Derom, J. Walter and M.P. Zeegers.
    DNA Methylation variability at growth-related imprints does not contribute to overweight in monozygotic twins discordant for BMI.
    Obesity 2011, Epub Jan 27.
  • Walter J.
    An epigenetic tet a tet with pluripotency.
    Cell Stem Cell. 2011 Feb 4;8(2):121-2.

2010

  • K. Lepikhov, M. Wossidlo, J. Arand und J. Walter.
    DNA methylation reprogramming and DNA repair in the mouse zygote.
    Int. J. Dev. Biol. 54: 1565-1574 (2010) doi: 10.1387/ijdb.103206kl
  • E. Tybl, F.D. Shi, S.M. Kessler, S. Tierling, J. Walter, R.M. Bohle, S. Wieland, J. Zhang, E.M. Tan and A.K. Kiemer.
    Overexpression of the IGF2-mRNA binding protein p62 in Transgenic Mice induces a Steatotic Phenotype.
    J Hepatol 2010, Epub Oct 26.
  • B. Hutter, M. Bieg, V. Helms and M. Paulsen.
    Imprinted genes show unique patterns of sequence conservation.
    BMC Genomics 2010, 11(1):649.
  • N. Pälmke, D. Santacruz and J. Walter.
    Comprehensive analysis of DNA-methylation in mammalian tissues using MeDIP-chip.
    Methods 2010, Epub Jul 16.
  • S. Tierling, N.Y. Souren, S. Reither, K.D. Zang, J. Meng-Hentschel, D. Leitner, B. Öhl-Jaschkowitz and J. Walter.
    DNA methylation studies on imprinted loci in a male monozygotic twin pair discordant for Beckwith-Wiedemann syndrome.
    Clin Genet. 2010, Epub Jun 7.
  • S. Tierling, M. Schuster, R. Tetzner and J. Walter.
    A combined HM-PCR/SNuPE method for high sensitive detection of rare DNA methylation.
    Epigenetics Chromatin. 2010, 3(1):12.
  • M. Wossidlo, J. Arand, V. Sebastiano, K. Lepikhov, M. Boiani, R. Reinhardt, H. Schöler and J. Walter.
    Dynamic link of DNA demethylation, DNA strand breaks and repair in mouse zygotes.
    Embo J. 2010, 29(11):1877-88.
  • B. Hutter, M. Bieg, V. Helms, and M. Paulsen.
    Divergence of imprinted genes during mammalian evolution.
    BMC Evol Biol. 2010, 10:116.

2009

  • S. Tierling, N.Y. Souren, J. Gries, C. Lo Porto, M. Groth, P. Lutsik, H. Neitzel, I. Utz-Billing, G. Gillessen-Kaesbach, H. Kentenich, G. Griesinger, K. Sperling, E. Schwinger, J. Walter.
    Assisted reproductive technologies do not enhance the variability of DNA methylation imprints in human.
    J Med Genet 2009. Epub Nov 30
  • D. Peters, K. Lepikhov, et al.
    Effect of IVF and laser zona dissection on DNA methylation pattern of mouse zygotes.
    Mammalian Genome 2009, 20(9-10): 664-73.
  • S. E. Racedo, C. Wrenzycki, K. Lepikhov, D. Salamone, J. Walter, H. Niemann.
    Epigenetic modifications and related mRNA expression during bovine oocyte in vitro maturation.
    Reprod Fertil Dev. 2009; 21(6):738-48. PMID: 19567217
  • B. Hutter, M. Paulsen, V. Helms.
    Identifying CpG islands by different computational techniques.
    OMICS: A Journal of Integrative Biology 2009. 13: 153-164.
  • S. Tierling, G. Gasparoni, N. Youngson, M. Paulsen.
    The Begain gene marks the centromeric boundary of the imprinted region on mouse chromosome 12.
    Mammalian Genome. 2009 Epub Jul 30.
  • C. Steinhoff, M. Paulsen, S. Kielbasa, J. Walter, M. Vingron.
    Expression profile and transcription factor binding site exploration of imprinted genes in human and mouse.
    BMC Genomics. 2009 Mar 31;10:144.
  • Y. Zhang, C. Rohde, S. Tierling, T. P. Jurkowski, C. Bock, D. Santacruz, S. Ragozin, R. Reinhardt, M. Groth, J. Walter, A. Jeltsch.
    DNA methylation analysis of chromosome 21 gene promoters at single base pair and single allele resolution.
    PLoS Genet 2009 5(3) : e1000438.
  • Y. Zhang, C. Rohde, S. Tierling, H. Stamerjohanns, R. Reinhardt, J. Walter, A. Jeltsch.
    DNA methylation analysis by bisulfite conversion, cloning, and sequencing of individual clones.
    Methods Mol Biol 2009 507: 177-87.

2008

  • C. Bock, J. Walter, M. Paulsen, T. Lengauer.
    Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping.
    Nucleic Acids Res, 2008 36(10): e55.
  • K. Lepikhov, V. Zakhartchenko, R. Hao, F. Yang, C. Wrenzycki, H. Niemannn, E. Wolf, J. Walter.
    Evidence for conserved DNA and histone H3 methylation reprogramming in mouse, bovine and rabbit zygotes.
    Epigenetics Chromatin 2008 1(1): 8.
  • M. Kirchner, C. Bock, M. Paulsen.
    Structural conservation versus functional divergence of maternally expressed microRNAs in the Dlk1/Gtl2 imprinting region.
    BMC Genomics 2008 9: 346.

2007

  • C. Bock, J. Walter, M. Paulsen, T. Lengauer.
    CpG island mapping by epigenome prediction.
    PLoS Comput Biol, 2007 3(6): e110.

2006

  • S. Tierling, S. Dalbert, S. Schoppenhorst, C.E. Tsai, S. Oliger, A. C. Ferguson-Smith, M. Paulsen, J. Walter.
    High-resolution map and imprinting analysis of the Gtl2-Dnchc1 domain on mouse chromosome 12.
    Genomics, 2006 87(2): 225-35.
  • C. Bock, M. Paulsen, S. Tierling, T. Mikeska, T. Lengauer, J. Walter.
    CpG island methylation in human lymphocytes is highly correlated with DNA sequence, repeats, and predicted DNA structure.
    PLoS Genet, 2006 2(3): e26.
  • J. Walter, B. Hutter, T. Khare, M. Paulsen.
    Repetitive elements in imprinted genes.
    Cytogenet Genome Res 2006 113(1-4): 109-15.
  • B. Hutter, V. Helms, M. Paulsen.
    Tandem repeats in the CpG islands of imprinted genes.
    Genomics 2006 88(3): 323-32.

2005

  • C. Bock, S. Reither, T. Mikeska, M. Paulsen , J. Walter, T. Lengauer.
    BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing.
    Bioinformatics. 2005 Nov 1;21(21):4067-8.
  • J. Derbinski, J. Gabler, B. Brors, S. Tierling, S. Jonnakuty, M. Hergenhahn, L. Peltonen, J. Walter, B. Kyewski.
    Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels.
    J Exp Med, 2005 202(1): 33-45.
  • O. El-Maarri, M. Seoud, J. B. Riviere, J. Oldenburg, J. Walter, G. Rouleau, R. Slim.
    Patients with familial biparental hydatidiform moles have normal methylation at imprinted genes.
    Eur J Hum Genet, 2005 13(4): 486-90.
  • M. Paulsen, T. Khare, C. Burgard, S. Tierling, J. Walter.
    Evolution of the Beckwith-Wiedemann syndrome region in vertebrates.
    Genome Res 15, 146-153.

2004

  • K. Lepikhov, J. Walter.
    Differential dynamics of histone H3 methylation at positions K4 and K9 in the mouse zygote.
    BMC Dev Biol, 2004, 4 (1), 12.
  • A. Lewis, K. Mitsuya, D. Umlauf, P. Smith, W. Dean, J. Walter, M. Higgins, R. Feil, W. Reik.
    Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation.
    Nat Genet, 2004, 36, 1291-1295.

2003

  • H. Seitz, N. Youngson, S.P. Lin, S. Dalbert, M. Paulsen, J.P. Bachellerie, A.C. Ferguson-Smith, J. Cavaille.
    Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene.
    Nature Genetics, 2003. 34: 261-262.
  • J. Walter, M. Paulsen.
    The potential roleene of gduplications in the evolution of imprinting mechanisms.
    Hum Mol Genet, 2003. 12 Spec No 2: p. R215-20.
  • J. Walter, M. Paulsen.
    Imprinting and disease.
    Semin Cell Dev Biol, 2003. 14 (1): p. 101-10.
  • S. Lopes, et al.
    Epigenetic modifications in an imprinting cluster are controlled by a hierarchy of DMRs suggesting long-range chromatin interactions.
    Hum Mol Genet, 2003. 12 (3): p. 295-305.
  • N. Lane, et al.
    Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse.
    Genesis, 2003. 35 (2): p. 88-93.
  • J. Hejnar, et al.
    Demethylation of host-cell DNA at the site of avian retrovirus integration.
    Biochem Biophys Res Commun, 2003. 311 (3): p. 641-8.

2002

  • D. Biniszkiewicz, et al.
    Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality.
    Mol Cell Biol, 2002. 22 (7): p. 2124-35.
  • O. El-Maarri, et al.
    A rapid, quantitative, non-radioactive bisulfite-SNuPE- IP RP HPLC assay for methylation analysis at specific CpG sites.
    Nucleic Acids Res, 2002. 30 (6): p. e25.
  • P. Hajkova, et al.
    Epigenetic reprogramming in mouse primordial germ cells.
    Mech Dev, 2002. 117 (1-2): p. 15.
  • P. Hajkova, et al.
    DNA-methylation analysis by the bisulfite-assisted genomic sequencing method.
    Methods Mol Biol, 2002. 200: p. 143-54.
  • E. A. Kubareva, et al.
    Determination of methylation site of DNA-methyltransferase NlaX by a hybrid method.
    Biotechniques, 2002. 33 (3): p. 526-31.
  • K. Kagotani, et al.
    Replication timing properties within the mouse distal chromosome 7 imprinting cluster.
    Biosci Biotechnol Biochem, 2002. 66 (5): p. 1046-51.
  • I. Stancheva, et al.
    DNA methylation at promoter regions regulates the timing of gene activation in Xenopus laevis embryos.
    Dev Biol, 2002. 243 (1): p. 155-65.

2001

  • W. Dean, et al.
    Conservation of methylation reprogramming in mammalian development: Aberrant reprogramming in cloned embryos.
    Proc Natl Acad Sci U S A, 2001. 98 (24): p. 13734-8.
  • O. El-Maarri, et al.
    Maternal methylation imprints on human chromosome 15 are established during or after fertilization.
    Nat Genet, 2001. 27 (3): p. 341-4.
  • S. Engemann, et al.
    Bisulphite-Based Methylation Analysis of Imprinted Genes
    Methods in Molecular Biology, A. Ward, Editor. 2001, HumanaPress: Totowa. p. 217-228.
  • E. A. Kubareva, et al.
    Determination of a non-methylated deoxycytidine residue in the recognition site of DNA-methyltransferases.
    Biochemistry (Mosc), 2001. 66 (12): p. 1356-60.
  • K. Lepikhov, et al.
    Characterization of the type IV restriction modification system BspLU11III from Bacillus sp. LU11.
    Nucleic Acids Res, 2001. 29 (22): p. 4691-8.
  • B. Pickard, et al.
    Epigenetic targeting in the mouse zygote marks DNA for later methylation: a mechanism for maternal effects in development.
    Mech Dev, 2001. 103 (1-2): p. 35-47.
  • M. Prissette, et al.
    Methylation profiles of DXPas34 during the onset of X-inactivation.
    Hum Mol Genet, 2001. 10 (1): p. 31-8.
  • W. Reik, W. Dean, J. Walter.
    Epigenetic reprogramming in mammalian development.
    Science, 2001. 293 (5532): p. 1089-93.
  • W. Reik, J. Walter.
    Evolution of imprinting mechanisms: the battle of the sexes begins in the zygote.
    Nat Genet, 2001. 27 (3): p. 255-6.
  • W. Reik, J. Walter.
    Genomic imprinting: parental influence on the genome.
    Nature Reviews Genetics, 2001. 2: p. 21-32.
  • P. Valenza-Schaerly, et al.
    A Dominant Modifier of Transgene Methylation Is Mapped by QTL Analysis to Mouse Chromosome 13.
    Genome Res, 2001. 11 (3): p. 382-388.

2000

  • W. Reik, et al.
    Igf2 imprinting in development and disease.
    Int J Dev Biol, 2000. 44 (1): p. 145-50.
  • M. Paulsen, et al.
    Sequence conservation and variability of imprinting in the beckwith- wiedemann syndrome gene cluster in human and mouse [In Process Citation].
    Hum Mol Genet, 2000. 9 (12): p. 1829-41.
  • W. Mayer, et al.
    Demethylation of the zygotic paternal genome.
    Nature, 2000. 403 (6769): p. 501-2.
  • A. Daser, et al.
    Genetics of atopy in a mouse model: polymorphism of the IL-5 receptor alpha chain.
    Immunogenetics, 2000. 51 (8-9): p. 632-8.
  • S. Engemann, et al.
    Sequence and functional comparison in the Beckwith-Wiedeman region: implications for a novel imprinting centre and extended imprinting.
    Hum Mol Genet, 2000. 9 (18): p. 2691-2706.
  • S. Takada, et al.
    Delta-like and gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12.
    Curr Biol, 2000. 10 (18): p. 1135-8.
  • J. Oswald, et al.
    Active demethylation of the paternal genome in the mouse zygote.
    Curr Biol, 2000. 10 (8): p. 475-8.