Wintersemester 2018-2019

Principles of Epigenetics and Genomics

The lectures provide an overview of epigenetic concepts and their relevance for human biology. Following an introduction into basic mechanisms and enzymologies of epigenetic control we will discus the developmental aspects of epigenetic modifications, particularly their importance for cell fate maintenance and cell function. Following a summary of disease related aspects we will briefly discus modern epigenomic mapping technologies and finally the basic principles of epigenetic data production, data managment and data interpretation.

Audience: Master Students of bioinformatics (biotechnology, biophysics and pharmacy) with basic knowledge in molecular genetics

The lecture will be held together with the Biology Master Students participating in the ADV-I module.

Lecturers:
Jörn Walter, Abdulrahman Salhab, Karl Nordström

Venue: Seminar Room 0.33, Building A2.4

Time: 8:30 - 10:00

Starting date: November 12th, daily until November 22nd, 2018
Last lecture: January 23rd, 2019, 16:00 - 17:30

Preliminary talk and registration: October, 17th, 17:00 !!!

Final registration is required in the University LSF system before November 12th !!!

Exam: 2019, February 13th, Building A4.3, microscopy room
Re-exam: 2019, April 2nd, Building A4.3, microscopy room


Lectures

pdf Overview

pdf Lecture121118

pdf Lecture131118

pdf Lecture141118

pdf Lecture151118

pdf Lecture161118

pdf Lecture191118

pdf Lecture201118

pdf Lecture211118


Suggested textbooks for Epigenetics:

"Epigenetics", by David Allis, Marie-Laure Caparros, Thomas Jenuwein, Danny Reinberg, Monika Lachlan, 2015, 984 pages, ISBN 978-1-936113-59-0

"Molekulare Genetik" (mit einem Kapitel über Epigenetik), Hrsg.: Alfred Nordheim, Rolf Knippers, 10. Auflage 2015, 568 S. , 620 Abb. , ISBN: 9783134770100 (only in german available)

Additional introductory literature for cancer epigenetics:
"Cancer Genetics and Epigenetics: Two Sides of the Same Coin?" Review by You & Jones http://dx.doi.org/10.1016/j.ccr.2012.06.008