Wintersemester 2019-2020

Principles of Epigenetics and Genomics

The lectures provide an overview of epigenetic concepts and their relevance for human biology. Following an introduction into basic mechanisms and enzymology of epigenetic control we will discus the developmental aspects of epigenetic modifications, particularly their importance for cell fate maintenance and cell function. Following a summary of disease related aspects the last four lectures will introduce into epigenomic mapping technologies, the basic principles of epigenetic data production, data management and data interpretation.

Audience: Master Students of bioinformatics (biotechnology, biophysics and pharmacy). Basic knowledge in molecular genetics is essential! The first 8 lectures will be held together with the Biology Master Students participating in the ADV-I module.

A successful passing of the test/examen is mandatory for the participation in a 3 day training module "Cloud based processing and joint evaluation of epigenomic data: RNA-seq, WGBS and ChIP-Seq data" to be held in march/april 2020 (2CP). The exact dates for this course will be set on october 15th during the briefing.


Teaching language: English

Lecturers:
Jörn Walter, Abdulrahman Salhab, Michael Scherer, Gilles Gasparoni

Venue: Seminar Room 0.33, Building A2.4
Content: Eleven lectures (90min each) in two blocks:
1. Block from 11th to 14th of November (= 8 lectures) with two lectures per day, 8:30 - 10:00am and 4 to 5:30 pm; and a
2. Block: November, 20th, 27th and December, 4th (3 lectures) at 8:30 - 10:00am, December, 5th at 12:15 - 1:45pm


Preliminary talk and introduction: October, 15th, 17:30 in room 0.33 in building A2.4!



Briefing and introduction to the entire lecture series: October, 15th, 17:30 in room 0.33 in building A2.4!

Final registration is required in the University LSF system before November 11th !!!

Exam: December 18th 2019 at 8:30 - 10:00am, buildg. A4 3, room 0.14.

pdf Results


Re-exam: 2020, early in April, Building A2.4,Room 0.33

pdf Results


Lectures

pdf Overview

pdf Introduction

pdf Chromatin I

pdf DNA-Methylation

pdf Chromatin II

pdf RNAs and epigenetic control

pdf Epigenetics and Development

pdf Epigenetics and Cancer

pdf Epigenomics

pdf Epigenomics II

pdf Epigenomic data analysis I

pdf Epigenomic data analysis II

pdf Epigenomic data analysis III


Suggested textbooks for Epigenetics:

"Epigenetics", by David Allis, Marie-Laure Caparros, Thomas Jenuwein, Danny Reinberg, Monika Lachlan, 2015, 984 pages, ISBN 978-1-936113-59-0

"Molekulare Genetik" (mit einem Kapitel über Epigenetik), Hrsg.: Alfred Nordheim, Rolf Knippers, 10. Auflage 2015, 568 S. , 620 Abb. , ISBN: 9783134770100 (only available in german)

Additional introductory literature for cancer epigenetics:
"Cancer Genetics and Epigenetics: Two Sides of the Same Coin?" Review by You & Jones http://dx.doi.org/10.1016/j.ccr.2012.06.008