winter-term 2017-2018

Principles of Epigenetics and Genomics

The lectures provide an overview of epigenetic concepts and their relevance for human biology. Following an introduction into basic mechanisms and enzymologies of epigenetic control we will discus the developmental aspects of epigenetic modifications, particularly their importance for cell fate maintenance and cell function. Following a summary of disease related aspects we will briefly discus modern epigenomic mapping technologies and finally the basic principles of epigenetic data production, data managment and data interpretation.

Audience: Master Students of bioinformatics (biotechnology, biophysics and pharmacy) with basic knowledge in molecular genetics

The lecture will be held together with the Biology Master Students participating in the ADV-I module.

Jörn Walter, Abdulrahman Salhab, Karl Nordström, Martin Simon

Venue: Seminar Room 0.01, Building A4.3 (Bld. for Life Science practicals)

Time: 8:30 - 10:00

Starting date: 13 November, daily until 23 November 2017
Last lecture: 23 November, 8:30 - 10:00

Preliminary talk and registration: 25 October, 17:00 !!!

Final registration is required in the University LSF system before November 13th !!!

Exam: January, 17th, 17:00, Building A2.4, seminar room 0.33
Re-exam: April, 3rd, 17:00, Building A2.4, seminar room 0.33

pdf Exam results

pdf Re-exam results

pdf Lecture overview

pdf L1 Introduction+Chromatin

pdf L2 Chromatin

pdf L3 regulatory RNA

pdf L4 DNA methylation

pdf L5 Epigenetics and Development

pdf L6 Epigenetics and Cancer

pdf L7 Epigenomics and Technologies

pdf L8 Epigenomics and data interpretation

pdf L9 Summary

Suggested textbooks for Epigenetics:

"Epigenetics", by David Allis, Marie-Laure Caparros, Thomas Jenuwein, Danny Reinberg, Monika Lachlan, 2015, 984 pages, ISBN 978-1-936113-59-0

"Molekulare Genetik" (mit einem Kapitel über Epigenetik), Hrsg.: Alfred Nordheim, Rolf Knippers, 10. Auflage 2015, 568 S. , 620 Abb. , ISBN: 9783134770100 (only in german available)

Additional introductory literature for cancer epigenetics:
"Cancer Genetics and Epigenetics: Two Sides of the Same Coin?" Review by You & Jones