winter-term 2020-2021

Principles of Epigenetics and Epigenomics

The lectures provide an overview of epigenetic concepts and their relevance for human biology. Following an introduction into basic mechanisms and enzymology of epigenetic control we will discus the developmental aspects of epigenetic modifications, particularly their importance for cell fate maintenance and cell function. Following a summary of disease related aspects the last four lectures will introduce into epigenomic mapping technologies, the basic principles of epigenetic data production, data management and data interpretation.

Audience: Master Students of bioinformatics (biotechnology, biophysics and pharmacy). Basic knowledge in molecular genetics is essential! The lectures will be held together with the Biology Master Students participating in the ADV-I module. Please register in the University LSF before November, 20th !

Teaching language: English

Lecturers:
Jörn Walter, Gilles Gasparoni, Kathrin Kattler, Konstantin Lepikhov

Venue: MS-Teams, Code: vqs1te4
Content: Nine lectures (90min each):
pdf Structure and Content


Exam: January 13th 2021 at 8:30 - 10:00am, buildg. A1.7, lecture hall.
Final registration is required in the University LSF system before December 18th !!!
Re-Exam: April 6th 2021 at 10:00 - 11:30am, buildg. A4.3, microscopy room.
Final registration is required in the University LSF system before March 12th !!!

Please be present at Bld.A1.7 at least 15 min prior to the start of the exam. Keep a distance of at least 1.5m when you enter or leave the building or the lecture hall. Chairs are labeled indicating the places to sit. It is obligate to wear a mouth mask when you enter or leave the building, lecture hall or the toilet rooms. There is no obligation to wear the mouth masks when writing the exam in the lecture hall.

pdf Schutzplan Klausur

pdf Safety regulations exam


If you are a student of Bioinformatics please register in LSF or in case of technical problems with registration please contact Dr. Björn Diehl (b.diehl@mx.uni-saarland.de). If you are a student of Biotechnology please write a registration mail to Prof. Walter (j.walter@mx.uni-saarland.de).


A successful passing of this test/examen is obligatory to receive the credit points for this lecture and to participate in the second lecture series in SS 2021 “Analysis of functional genomics data” (Lecture + practical course).

pdf Results

pdf Results Re-Exam



Lectures

pdf Lecture_301120

pdf Lecture_011220

pdf Lecture_021220

pdf Lecture_041220

pdf Lecture_071220

pdf Lecture_081220

pdf Lecture_091220

pdf Lecture_101220

pdf Lecture_111220

pdf Summary_151220

pdf Summary_080121



Suggested textbooks for Epigenetics:

"Epigenetics", by David Allis, Marie-Laure Caparros, Thomas Jenuwein, Danny Reinberg, Monika Lachlan, 2015, 984 pages, ISBN 978-1-936113-59-0

"Molekulare Genetik" (mit einem Kapitel über Epigenetik), Hrsg.: Alfred Nordheim, Rolf Knippers, 10. Auflage 2015, 568 S. , 620 Abb. , ISBN: 9783134770100 (only available in german)

Additional introductory literature for cancer epigenetics:
"Cancer Genetics and Epigenetics: Two Sides of the Same Coin?" Review by You & Jones http://dx.doi.org/10.1016/j.ccr.2012.06.008